Can we see what is inside living cells without subverting them?



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Vital survey tools have been an important and essential part of knowing what is inside the bodies of organisms in general, and our human bodies in particular, especially for the diagnosis of diseases and surgeries. 
For a long time, the idea of ​​seeing inside living cells by ultrasound waves has been very difficult without ruining the living cell. 
Today, researchers from the Optics and Photonics Group at the University of Nottingham University have developed an ultrasound technique that allows them to see inside living cells on a scale that would not have been possible without ruining the living cell.
In a paper published in Nature Scientific Reports, they stated in detail that this technique uses sound instead of light, so we will exceed the current limits of microscopy. 
The work of this technique can be summed up mainly by high-end ultrasound ultrasound. High-frequency sound waves are transmitted by the machine, and they enter through the sample until they somehow collide with the boundary and are reflected. Then the reflected waves are collected by a probe to analyze them. Uses the time needed by the technique to send the wave back to the probe to calculate the distance between the boundary, and then combine these data to form a three-dimensional image of the sample. 
According to Phys.org, Professor Matt Clarke, co-author of the study, said: "People know ultrasound as a way of seeing what's inside the body, in the simplest conditions we designed so much that we can see what's inside a single cell. Currently Nottingham is the only place in the world that has this capability. "
In the normal light microscope, which uses light (photons), the smaller body size you can see is specific to the wavelength. 
In biological samples, the wavelength can not be shorter than the wavelength of blue light because the energy of light photons in the ultraviolet (and shorter wavelengths) can destroy the bonds that bind the biomolecules together and thus destroy the cells. 
High-resolution optical imaging has clear limitations in biomedical studies. This is because the glossy pigment you use is usually poisonous, and you need large amounts of light and time to observe and reconstruct the image, which destroys the cells.
In contrast to the light, the sound does not have a large load of energy. This has enabled researchers in Nottingham to use smaller wavelengths and see smaller objects and obtain higher resolution without damaging the living cell. 
Because the cells studied remain intact, scientists can return them to the living body, which will lead us to new therapeutic options for diseases or even in the fight against aging.
Source phys.org

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